Protein Interaction Antibody Pairs
Sino Biological Recombinant Human Calreticulin/CALR Protein (Low Endotoxin)
A DNA sequence encoding the Human CALR (P27797) (Met1-Ala413) was expressed.
Revvity Health Sciences Inc HTRF Human & Mouse Total Wee1 Detection Kit, 50,000 Assay Points
HTRF Human & Mouse Total Wee1 Detection Kit, 50,000 Assay Points
ABclonal Technology LAMC1 Rabbit pAb
Laminins are extracellular matrix glycoproteins that form the major noncollagenous component of basement membranes, involved in processes like cell adhesion, differentiation, migration, and metastasis. They consist of three non-identical chains: alpha, beta, and gamma, forming a cruciform structure. Each chain is encoded by a distinct gene with multiple isoforms. Different combinations of alpha, beta, and gamma chains form various laminin isoforms, such as laminin 1 (alpha1beta1gamma1). The functions of these chains are not fully understood, though their tissue distribution suggests diverse roles. This gene encodes the gamma 1 chain isoform. Unlike the beta chain, it lacks a short alpha region. Inactivation of both gamma 1 chain alleles in transgenic mice causes a lack of basement membranes, showing its role in laminin assembly. Multiple polyadenylation sites generate two mRNA variants (5.5 and 7.5 kb) in humans.
Revvity Health Sciences Inc HTRF Human Phospho-FGFR4 (Tyr642) Detection Kit, 50,000 Assay Points
HTRF Human Phospho-FGFR4 (Tyr642) Detection Kit, 50,000 Assay Points
ABclonal Technology FGFR4 Rabbit mAb
The protein encoded by this gene is a tyrosine kinase and cell surface receptor for fibroblast growth factors. The encoded protein is involved in the regulation of several pathways, including cell proliferation, cell differentiation, cell migration, lipid metabolism, bile acid biosynthesis, vitamin D metabolism, glucose uptake, and phosphate homeostasis. This protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment, and a cytoplasmic tyrosine kinase domain. The extracellular portion interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation.
ABclonal Technology Phospho-eIF4EBP1-T70
This gene encodes one member of a family of translation repressor proteins The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E) which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5 end of mRNAs Interaction of this protein with eIF4E inhibits complex assembly and represses translation This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling resulting in its dissociation from eIF4E and activation of mRNA translation
ABclonal Technology AXIN1 Rabbit pAb
This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Alternative splicing results in multiple transcript variants.
ABclonal Technology MYL2 Rabbit pAb
This gene encodes a major sarcomeric protein in mammalian striated muscle. The encoded protein plays a role in embryonic heart muscle structure and function, while phosphorylation of the encoded protein is involved in cardiac myosin cycling kinetics, torsion and function in adults. Mutations in this gene are associated with hypertrophic cardiomyopathy 10 and infant-onset myopathy.
ABclonal Technology PLC gamma 1 (PLCG1) Rabbit mAb
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene.