Protein Interaction Antibody Pairs
ABclonal Technology p-PLC gamma 2 PLCG2-Y1217
The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4 5-bisphosphate to 1D-myo-inositol 1 4 5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane Mutations in this gene have been found in autoinflammation antibody deficiency and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3
ABclonal Technology p-GSK3B-Y216 - GSK3a-Y279
The protein encoded by this gene is a serine-threonine kinase belonging to the glycogen synthase kinase subfamily It is involved in energy metabolism neuronal cell development and body pattern formation Polymorphisms in this gene have been implicated in modifying risk of Parkinson disease and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease Alternatively spliced transcript variants encoding different isoforms have been found for this gene
ABclonal Technology p-PLC gamma 1 PLCG1-S1248
The protein encoded by this gene catalyzes the formation of inositol 1 4 5-trisphosphate and diacylglycerol from phosphatidylinositol 4 5-bisphosphate This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators For example when activated by SRC the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi where it activates Ras Also this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase Two transcript variants encoding different isoforms have been found for this gene
ABclonal Technology Phospho-GSK3B-S9 Mouse mAb
The protein encoded by this gene is a serine-threonine kinase belonging to the glycogen synthase kinase subfamily It is a negative regulator of glucose homeostasis and is involved in energy metabolism inflammation ER-stress mitochondrial dysfunction and apoptotic pathways Defects in this gene have been associated with Parkinson disease and Alzheimer disease
Revvity Health Sciences Inc HTRF Human & Mouse Total Wee1 Detection Kit, 500 Assay Points
HTRF Human & Mouse Total Wee1 Detection Kit, 500 Assay Points
Revvity Health Sciences Inc HTRF Human Phospho-FGFR4 (Tyr642) Detection Kit, 50,000 Assay Points
HTRF Human Phospho-FGFR4 (Tyr642) Detection Kit, 50,000 Assay Points
Cusabio Technology LLC Recombinant Human Claudin-3 CLDN3 VLPs active20ug
Recombinant Human Claudin-3 CLDN3 VLPs active20ug
BIORTUS USA INC Gene Name: CDK4/CCND3. Uniprot: P11802/P30281. Construct:GST-3C-CDK4(1-303end)/His-3C-Cyclin D3(1-292). Purity: 80%. 1 each contains 100UG.
Ser/Thr-kinase component of Cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Component of the ternary complex, Cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the Cyclin D-CDK4 complex. Shows transcriptional coactivator activity with ATF5 independently of CDK4.